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Immunogenicity of injectable collagen implants
P H Sellem1, F R Caranzan, M C Bene
1Laboratoire d'Immunologie, UFR Sciences Médicales, Vandoeuvre les Nancy, France.
The Journal of Dermatologic Surgery and Oncology
|November 1, 1987
Abstract:
The presence of antibodies to bovine and human collagens used in injectable collagen implants (ICI) was investigated in 103 normal sera. Significant levels of spontaneous nonprecipitin antibodies were observed, suggesting that immunization to ICI compounds may preexist even in the absence of connective tissue disease.