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Metaplastic breast cancer: A review
Horatio R Thomas1, Bonnie Hu2, Baris Boyraz3
1Department of Radiation Oncology, University of California, San Francisco, United States.
Critical Reviews in Oncology/Hematology
|January 25, 2023
Summary
Metaplastic breast cancer (MpBC) is a rare and aggressive cancer with a poor prognosis. This review synthesizes current data on MpBC features, treatment, and outcomes, identifying targets for future research.
Area of Science:
- Oncology
- Pathology
- Genomics
Background:
- Metaplastic breast cancer (MpBC) is a rare subtype of breast cancer.
- MpBC is characterized by aggressive behavior and a poor clinical prognosis.
- Limited understanding exists regarding MpBC's clinical-pathological features, treatment, and outcomes due to its rarity.
Purpose of the Study:
- To review and synthesize current data on metaplastic breast cancer.
- To explore the clinical, pathological, and genomic characteristics of MpBC.
- To identify potential therapeutic targets for future clinical trials in MpBC.
Main Methods:
- Comprehensive literature review of existing studies on MpBC.
- Synthesis of data on clinical presentation, pathological findings, and genomic alterations.
- Analysis of current treatment strategies and patient outcomes.
Main Results:
- MpBC presents unique clinical and pathological features distinct from other breast cancers.
- Treatment approaches and outcomes for MpBC are variable and often associated with poor prognosis.
- Genomic landscape of MpBC reveals potential therapeutic vulnerabilities.
Conclusions:
- Further research is needed to fully elucidate MpBC biology and optimize treatment.
- Identifying specific therapeutic targets is crucial for improving outcomes in metaplastic breast cancer patients.
- This review provides a foundation for future clinical trials investigating novel MpBC therapies.
Keywords:
Clinical managementClinical outcomesEpithelial-to-mesenchymal transitionImmunotherapyMetaplastic breast cancerPathologyTargeted therapy
