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Updated: Aug 12, 2025
10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
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Immune checkpoint inhibitor-mediated hypophysitis: no place like home
Tim Cooksley1, Tom Knight2, Duncan Lindsay2
1The Christie, Manchester, UK cooks199@hotmail.com.
Clinical Medicine (London, England)
|January 25, 2023
Summary
Ambulatory emergency care safely manages immune checkpoint inhibitor (ICI)-mediated hypophysitis. Patients received intravenous then oral hydrocortisone, avoiding hospital readmission and mortality, allowing continued cancer therapy.
Area of Science:
- Endocrinology
- Oncology
- Emergency Medicine
Background:
- Immune checkpoint inhibitors (ICIs) can cause life-threatening hypophysitis.
- Ambulatory emergency care is key for sustainable acute services.
Purpose of the Study:
- To evaluate a novel ambulatory pathway for managing ICI-mediated hypophysitis.
- To assess the safety and efficacy of same-day hydrocortisone treatment for hypophysitis.
Main Methods:
- Patients with non-severe ICI-hypophysitis received IV hydrocortisone, observation, and oral discharge.
- Follow-up occurred in endocrinology outpatient clinics.
- Fourteen patients were managed via this pathway.
Main Results:
- All 14 patients had confirmed ACTH deficiency.
- No 30-day readmissions or hypophysitis-related deaths occurred.
- All patients continued ICI therapy without interruption.
Conclusions:
- An ambulatory pathway for ICI-hypophysitis is safe and effective.
- This approach facilitates continued cancer treatment.
- It reduces healthcare burden without compromising patient outcomes.
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