Related Experiment Videos
Evaluation of a readily-fabricated infusion device
1Institute of Biomedical Engineering, Faculty of Medicine, University of Toronto, Ontario, Canada.
Life Support Systems : the Journal of the European Society for Artificial Organs
|April 1, 1987
Summary
Researchers developed a low-cost, adaptable plastic infusion device for controlled drug delivery. This novel device maintained stable, low flow rates in laboratory tests and demonstrated effective heparin delivery in vivo.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Controlled-release drug delivery is crucial in clinical and research settings.
- Existing infusion pumps are often expensive and difficult to customize.
- There is a need for cost-effective and adaptable drug delivery solutions.
Purpose of the Study:
- To develop and evaluate a novel, low-cost plastic infusion device for controlled drug delivery.
- To assess the device's ability to maintain consistent, low flow rates.
- To demonstrate the device's efficacy in vivo for drug administration.
Main Methods:
- Fabrication of a plastic infusion device using readily available laboratory materials.
- Inclusion of a collapsible reservoir, protective double jacket with vents, and a hollow glass-fibre flow moderator.
- In vivo testing on Wistar rats using heparin solution to assess anticoagulant release.
Main Results:
- The device successfully maintained stable flow rates as low as 100 microliter/h without occlusion.
- In vivo studies showed controlled release of heparin, evidenced by delayed Lee-White clotting time.
- The device design allows for adjustable size, service life, and flow rate.
Conclusions:
- The fabricated plastic infusion device offers a cost-effective and adaptable alternative to existing pumps.
- The device demonstrates reliable performance for controlled drug delivery, suitable for various experimental needs.
- This technology holds potential for adapting to the delivery requirements of diverse pharmaceutical agents.