Dietary inflammatory potential and psoriasis: A cross-sectional study.

Area of Science:

• Nutrition Science
• Dermatology
• Epidemiology

Background:

• Diet significantly influences systemic inflammation.
• Diet-induced inflammation is a potential factor in psoriasis pathogenesis.
• The Dietary Inflammatory Index (DII) quantifies individual dietary inflammatory potential.

Purpose of the Study:

• To investigate the association between the Dietary Inflammatory Index (DII) and incident psoriasis.
• To explore potential nonlinear relationships between DII and psoriasis risk.

Main Methods:

• Cross-sectional study using National Health and Nutrition Examination Surveys (2003-2006, 2009-2014).
• DII calculated from 24-hour dietary recalls.
• Psoriasis status determined by self-reported medical questionnaire.
• Multivariable logistic regression and restricted cubic splines (RCS) analyzed the association.

Main Results:

• A total of 13,284 participants were analyzed; psoriasis prevalence was 2.88%.
• No significant association was found between DII and incident psoriasis (OR=1.00, 95% CI 0.89-1.11).
• Subgroup analyses and RCS confirmed no overall or nonlinear relationship between DII and psoriasis.

Conclusions:

• This cross-sectional study indicates no association between dietary inflammatory potential (DII) and psoriasis occurrence.
• While a pro-inflammatory diet poses health risks, its direct link to psoriasis incidence requires further investigation.
• Future research should explore other dietary patterns or mechanisms in relation to psoriasis.