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Updated: Aug 12, 2025
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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
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Rate of Patch Testing Induced Anaphylaxis
Karishma Daftary1, Andrew Scheman1,2, Heidi Bai3
1From the Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago.
Dermatitis : Contact, Atopic, Occupational, Drug
|January 27, 2023
Summary
Anaphylaxis during patch testing is rare, occurring at an estimated rate of 1 in 100,860 tests. Patients with a history of anaphylaxis may be at higher risk, necessitating preparedness among dermatologists.
Area of Science:
- Dermatology
- Allergy and Immunology
Background:
- Allergic contact dermatitis is a Type IV hypersensitivity reaction.
- Type I hypersensitivity reactions, including anaphylaxis, have been reported during patch testing.
Approach:
- Literature review on PubMed for reported anaphylaxis cases post-patch testing.
- Survey distributed to expert dermatologists to estimate the rate of anaphylaxis.
Key Points:
- Three cases of anaphylaxis from patch testing identified in the literature.
- Survey of 27 expert dermatologists revealed 2 cases of anaphylaxis in an estimated 201,720 tested patients.
- Calculated rate of patch testing-induced anaphylaxis is approximately 1 in 100,860.
Conclusions:
- Anaphylaxis induced by patch testing is a rare event.
- Patients with a prior history of anaphylaxis may be more susceptible.
- Dermatologists should maintain a management plan for rare instances of patch test anaphylaxis.
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