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Related Experiment Video

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Measuring Local Anaphylaxis in Mice
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Rate of Patch Testing Induced Anaphylaxis.

Karishma Daftary1, Andrew Scheman1,2, Heidi Bai3

  • 1From the Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago.

Dermatitis : Contact, Atopic, Occupational, Drug
|January 27, 2023
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Summary
This summary is machine-generated.

Anaphylaxis during patch testing is rare, occurring at an estimated rate of 1 in 100,860 tests. Patients with a history of anaphylaxis may be at higher risk, necessitating preparedness among dermatologists.

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Area of Science:

  • Dermatology
  • Allergy and Immunology

Background:

  • Allergic contact dermatitis is a Type IV hypersensitivity reaction.
  • Type I hypersensitivity reactions, including anaphylaxis, have been reported during patch testing.

Approach:

  • Literature review on PubMed for reported anaphylaxis cases post-patch testing.
  • Survey distributed to expert dermatologists to estimate the rate of anaphylaxis.

Key Points:

  • Three cases of anaphylaxis from patch testing identified in the literature.
  • Survey of 27 expert dermatologists revealed 2 cases of anaphylaxis in an estimated 201,720 tested patients.
  • Calculated rate of patch testing-induced anaphylaxis is approximately 1 in 100,860.

Conclusions:

  • Anaphylaxis induced by patch testing is a rare event.
  • Patients with a prior history of anaphylaxis may be more susceptible.
  • Dermatologists should maintain a management plan for rare instances of patch test anaphylaxis.