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Bixin-loaded colloidal nanodelivery systems, techniques and applications.

Ayesheh Enayati1, Atefe Rezaei2, Seid Reza Falsafi3

  • 1Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Food Chemistry
|January 29, 2023
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Summary
This summary is machine-generated.

Bixin, a natural food colorant, faces stability issues. Nanodelivery systems offer improved bioavailability and applications for this annatto-derived carotenoid.

Keywords:
BioavailabilityBixinFood industryHealth benefitsNanocarriersNanoencapsulation

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Area of Science:

  • Food Science and Technology
  • Materials Science
  • Pharmacology

Background:

  • Bixin, a liposoluble apocarotenoid from annatto, is FDA-approved as a food colorant.
  • Bixin exhibits poor stability against oxygen, light, heat, and alkali, limiting its bioavailability and water solubility.
  • Existing challenges necessitate advanced delivery systems to enhance bixin's efficacy and application range.

Approach:

  • This review synthesizes current research on biopolymeric and lipid-based nanocarriers for bixin encapsulation.
  • Focuses on nanoencapsulation strategies to overcome bixin's inherent instability and solubility limitations.
  • Evaluates various nanodelivery platforms, including nanofibers, nanogels, nanotubes, nanoliposomes, niosomes, hexosomes, nanoemulsions, solid-lipid nanoparticles, and nanostructured lipid carriers.

Key Points:

  • Nanoencapsulation significantly improves bixin's physicochemical properties, bioavailability, and stability.
  • Different nanocarriers exhibit varying release rates and efficiencies for bixin.
  • Nanoencapsulated bixin demonstrates potential for broader applications in food and other industries.

Conclusions:

  • Nanodelivery platforms are crucial for managing bixin's instability and enhancing its functional properties.
  • Further research into nanocarrier design and safety is warranted for optimal bixin utilization.
  • Advanced nanoencapsulation strategies can unlock the full potential of bixin as a valuable additive.