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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
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Worldwide Glycoscience Informatics Infrastructure: The GlySpace Alliance
Frederique Lisacek1,2, Michael Tiemeyer3, Raja Mazumder4
1Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, University of Geneva, Geneva CH-1227, Switzerland.
JACS Au
|January 30, 2023
Summary
The GlySpace Alliance unifies three major glycoscience portals (Glyco@Expasy, GlyCosmos, GlyGen) to provide consistent glycan data. This integration enhances user access to chemical structures and functions of glycans.
Area of Science:
- Glycoscience
- Bioinformatics
- Computational Biology
Background:
- Three major glycoscience portals (Glyco@Expasy, GlyCosmos, GlyGen) exist in Europe, Asia, and the US.
- These portals currently have distinct user interfaces and data presentation.
Purpose of the Study:
- To introduce the GlySpace Alliance, formed in 2018.
- To harmonize the basic dataset of glycan-related omics data across the three portals.
- To enable efficient user retrieval of information on glycan chemical structures and functions.
Main Methods:
- Formation of the GlySpace Alliance by principal investigators of the three portals.
- Standardization of core glycan-related omics data.
- Development of a unified approach for data accessibility.
Main Results:
- Establishment of a collaborative alliance integrating major glycoscience portals.
- Aims to provide a consistent dataset of glycan structures and functions.
- Improved efficiency for users seeking specific glycan information.
Conclusions:
- The GlySpace Alliance facilitates a more integrated and user-friendly approach to glycoscience data.
- Harmonization of data across portals enhances research accessibility.
- Future efforts will focus on seamless user experience for exploring glycan information.
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