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Intestinal absorption at high altitude.

I M Chesner1, N A Small, P W Dykes

  • 1Department of Medicine, East Birmingham Hospital, UK.

Postgraduate Medical Journal
|March 1, 1987
PubMed
Summary
This summary is machine-generated.

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High altitude does not appear to cause malabsorption in the small intestine up to 4846 meters. However, further research is needed for extreme altitudes like 5600 meters.

Area of Science:

  • Physiology
  • Altitude Medicine
  • Gastroenterology

Background:

  • High altitude environments present physiological challenges.
  • Understanding small intestinal function at altitude is crucial for adaptation.
  • Previous studies on malabsorption at high altitudes are limited.

Purpose of the Study:

  • To investigate potential malabsorption in the small intestine at high altitudes.
  • To assess the impact of different altitudes (3100 m and 4846 m) on intestinal function.
  • To evaluate specific markers of nutrient absorption.

Main Methods:

  • Performed three small intestinal function tests at 3100 m and 4846 m.
  • Administered xylose tolerance tests and oxalate loading tests.
  • Conducted direct fat absorption tests measuring chylomicron levels.

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Main Results:

  • Xylose tolerance remained unchanged at 3100 m and 4846 m in most subjects.
  • One subject showed lower one-hour xylose levels at an extreme altitude of 5600 m.
  • Oxalate loading tests did not indicate significant fat malabsorption.
  • Direct fat absorption tests revealed increased chylomicron levels at high altitude.

Conclusions:

  • No significant evidence of small intestinal malabsorption was found up to 4846 m.
  • The observed increase in chylomicron levels suggests altered fat processing at high altitude.
  • Further investigation is warranted for extreme altitudes above 5000 m.