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PROGNOSTIC ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE CARDIOVASCULAR COMPLICATIONS DEVELOPMENT IN PATIENTS

Valeriya D Nemtsova1, Olena V Vysotska2, Hanna M Strashnenko2

  • 1EDUCATIONAL AND SCIENTIFIC MEDICAL INSTITUTE OF NATIONAL TECHNICAL UNIVERSITY «KHARKIV POLYTECHNIC INSTITUTE», KHARKIV, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|February 1, 2023
PubMed

Insights

Elevated vascular endothelial growth factor (VEGF) levels predict cardiovascular complications in patients with hypertension, type 2 diabetes, and subclinical hypothyroidism. Measuring VEGF offers a valuable prognostic tool for this complex comorbidity.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Medicine
  • Biomarker Research

Background:

  • Cardiovascular complications pose a significant risk in patients with comorbid hypertension, type 2 diabetes mellitus, and subclinical hypothyroidism.
  • Identifying reliable prognostic markers is crucial for managing this complex patient group.

Purpose of the Study:

  • To investigate the prognostic value of vascular endothelial growth factor (VEGF) levels in predicting cardiovascular complications.
  • To assess VEGF as a potential biomarker in patients with the combined comorbidity of hypertension, type 2 diabetes, and subclinical hypothyroidism.

Main Methods:

  • A cohort of 93 patients with hypertension, type 2 diabetes, and subclinical hypothyroidism was studied over 12 months.
  • Vascular endothelial growth factor (VEGF) levels were measured using ELISA, alongside assessments of metabolic parameters and blood pressure.
  • Receiver Operating Characteristic (ROC) analysis was employed to determine predictive thresholds.

Main Results:

  • VEGF levels were significantly higher in the patient group compared to controls (482.77±21.34 pg/ml vs. 121.84±11.66 pg/ml, p <0.001).
  • A VEGF level of ≥ 512.31 pg/ml was identified as a potential threshold for cardiovascular complication development.
  • Patients developing complications had significantly higher VEGF levels (650.76±52.04 pg/ml) than the threshold, while those without complications had levels below the threshold (420.47±21.67 pg/ml).

Conclusions:

  • Plasma vascular endothelial growth factor (VEGF) levels can serve as a prognostic indicator.
  • VEGF measurement aids in evaluating long-term outcomes for patients with comorbid hypertension, type 2 diabetes mellitus, and subclinical hypothyroidism.
Abstract

Keywords:
cardiovascular complicationsvascular endothelialgrowth factorhypertensionsubclinical hypothyroidismtype 2 diabetes mellitus

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