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Updated: Aug 12, 2025

Single-Molecule Dwell-Time Analysis of Restriction Endonuclease-Mediated DNA Cleavage
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Controlling DNA nanodevices with light-switchable buffers.

Valentin Jean Périllat1, Erica Del Grosso2, Cesare Berton1

  • 1Institut des Sciences et Ingénierie Chimiques École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Chemical Communications (Cambridge, England)
|February 2, 2023
PubMed
Summary
This summary is machine-generated.

Researchers demonstrate visible light control for DNA nanodevices using photo-switchable buffers. This non-invasive method enables remote, programmable manipulation of nanodevice functions like cargo loading and release.

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Area of Science:

  • Nanotechnology
  • Synthetic Biology
  • Biochemistry

Background:

  • DNA nanodevices offer precise molecular construction.
  • Controlling DNA nanodevices typically requires chemical modification or invasive physical methods.
  • Light-actuation is desirable but challenging without altering DNA.

Purpose of the Study:

  • To develop a non-invasive method for controlling DNA nanodevices using visible light.
  • To demonstrate reversible and programmable actuation of DNA nanodevices.
  • To enable remote control of complex nanodevice operations.

Main Methods:

  • Utilizing photo-switchable aqueous buffer solutions.
  • Employing visible light as the external stimulus.
  • Designing and testing DNA nanodevices for cargo loading/release.

Main Results:

  • Achieved reversible control of DNA nanodevices with visible light.
  • Demonstrated highly programmable actuation without modifying DNA.
  • Successfully controlled the reversible release and loading of cargo molecules.

Conclusions:

  • Visible light can effectively control DNA nanodevices via photo-switchable buffers.
  • This non-invasive approach offers remote and programmable operation.
  • The method is suitable for complex tasks like cargo manipulation.