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"Smart" Stimuli-responsive Injectable Gels for Bone Tissue Engineering Application.

Hanke Li1, Zhuowen Hao1, Shuwei Zhang1

  • 1Department of Orthopedics, Zhongnan Hospital of Wuhan University, Donghu Road 169 430071, China.

Macromolecular Bioscience
|February 2, 2023
PubMed
Summary
This summary is machine-generated.

Injectable gels (IGs) offer promising alternatives to bone grafting for bone damage. These stimuli-responsive biomaterials provide customizable functions and improved surgical viability, advancing bone tissue engineering.

Keywords:
drug deliveryinjectabilitysmart hydrogelsstimuli-responsivetissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Bone grafting faces limitations in sourcing and application for large bone defects.
  • Tissue engineering offers advanced substitutes with enhanced biocompatibility and customizable functions.
  • Injectable gels (IGs) are emerging as promising biomaterials due to their non-invasive delivery and in vivo responsiveness.

Purpose of the Study:

  • To review the mechanics of stimuli-responsive injectable gels developed over the past decade.
  • To introduce the composition and customization of covalent and non-covalent crosslinked IGs.
  • To summarize current trends and future outlooks in bone tissue engineering using IGs.

Main Methods:

  • Literature review focusing on stimuli-responsive injectable gels.
  • Analysis of gel mechanics, crosslinking strategies (covalent and non-covalent), and customization.
  • Synthesis of current research trends and future perspectives in the field.

Main Results:

  • Stimuli-responsive IGs demonstrate significant potential as advanced biomaterials for bone tissue engineering.
  • Both covalent and non-covalent crosslinked IGs offer distinct advantages in composition and customization.
  • The review illustrates the mechanics and in vivo responsiveness of these injectable gel systems.

Conclusions:

  • Injectable gels represent a significant advancement in bone tissue engineering, offering viable alternatives to traditional bone grafting.
  • The development of stimuli-responsive IGs provides enhanced biocompatibility, accessibility, and tunable functionalities.
  • This review serves as a reference for future research and development of novel injectable gel biomaterials for bone regeneration.