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Related Experiment Video

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Functional System Based on Glycyrrhizic Acid Supramolecular Hydrogel: Toward Polymorph Control, Stabilization, and

Weiqi Liu1, Zhiqiang Li1, Zixuan Wang1

  • 1Guangdong Provincial Key Lab of Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou510640, China.

ACS Applied Materials & Interfaces
|February 2, 2023
PubMed
Summary

Natural glycyrrhetinic acid hydrogels effectively control and stabilize the metastable gamma form of pyrazinamide. This drug delivery system offers pH-responsive, targeted release, enhancing drug efficacy and stability.

Keywords:
control releasedrug delivery systemglycyrrhizic acid gelpolymorph controlpolymorph stabilizationpyrazinamide

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Area of Science:

  • Materials Science
  • Pharmaceutical Science
  • Biotechnology

Background:

  • Drug delivery systems (DDS) using natural supramolecular hydrogels offer biocompatibility and tunable performance.
  • Designing functional hydrogel DDS with controlled drug interactions remains a challenge.

Purpose of the Study:

  • To develop a simple and efficient hydrogel DDS using glycyrrhetinic acid (GA) gel to encapsulate and control pyrazinamide (PZA).
  • To investigate the polymorph control, stabilization, and pH-responsive release of PZA within the GA hydrogel.

Main Methods:

  • Encapsulation of pyrazinamide (PZA) in a natural glycyrrhetinic acid (GA) hydrogel.
  • Characterization using Powder X-ray diffraction (PXRD), spectral analysis, and molecular dynamics simulation.
  • In vitro drug release studies under varying pH conditions.

Main Results:

  • GA gel successfully produced and stabilized the metastable gamma form of PZA.
  • Carboxyl-amide interactions at the gel-drug interface mediated PZA polymorphism and enhanced stability for 3 months.
  • The GA hydrogel demonstrated pH-responsive, targeted release of PZA.

Conclusions:

  • Glycyrrhetinic acid hydrogels provide a promising platform for DDS with integrated polymorph control and stabilization.
  • The developed system enhances drug stability and enables targeted, pH-responsive drug delivery.