Learned regularization for image reconstruction in sparse-view photoacoustic tomography

Constrained data acquisitions, such as sparse view measurements, are sometimes used in photoacoustic computed tomography (PACT) to accelerate data acquisition. However, it is challenging to reconstruct high-quality images under such scenarios. Iterative image reconstruction with regularization is a typical choice to solve this problem but it suffers from image artifacts. In this paper, we present a learned regularization method to suppress image artifacts in model-based iterative reconstruction in sparse view PACT. A lightweight dual-path network is designed to learn regularization features from both the data and the image domains. The network is trained and tested on both simulation and in vivo datasets and compared with other methods such as Tikhonov regularization, total variation regularization, and a U-Net based post-processing approach. Results show that although the learned regularization network possesses a size of only 0.15% of a U-Net, it outperforms other methods and converges after as few as five iterations, which takes less than one-third of the time of conventional methods. Moreover, the proposed reconstruction method incorporates the physical model of photoacoustic imaging and explores structural information from training datasets. The integration of deep learning with a physical model can potentially achieve improved imaging performance in practice.