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Updated: Aug 11, 2025
Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers
Atanu Ghosh1, Masaaki Akabane-Nakata2, Jayanta Kundu1
1School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.
Abstract:
We report the synthesis of piperidino nucleoside phosphoramidates functionalized with uracil, cytosine, guanine, and adenine and their incorporation into oligomers. High-performance liquid chromatography analyses demonstrated that a phosphorodiamidate piperidino oligomer (PPO) is more lipophilic than a phosphorodiamidate morpholino oligomer (PMO) of the same tetrameric sequence. A PMO containing piperidino residues formed duplexes with both DNA and RNA, and the PPO had higher stability at endosomolytic pH and higher hydrophobicity than the PMO.
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