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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

674
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
674
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

516
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
516
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

604
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
604

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Chákṣu: A glaucoma specific fundus image database.

J R Harish Kumar1, Chandra Sekhar Seelamantula2, J H Gagan3

  • 1Department of Electrical and Electronics Engineering, Manipal Institute of Technology Manipal, Manipal Academy of Higher Education, Manipal, 576104, India. harishkumar.jr@manipal.edu.

Scientific Data
|February 3, 2023
PubMed
Summary
This summary is machine-generated.

Chákṣu, a new Indian retinal image database, aids glaucoma diagnosis. This large dataset with expert annotations supports AI development for computer-assisted glaucoma prescreening.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Computer Science

Background:

  • Glaucoma diagnosis relies on expert interpretation of retinal fundus images.
  • Developing automated glaucoma detection systems requires large, annotated datasets.
  • Existing databases may lack diversity or comprehensive expert annotations.

Purpose of the Study:

  • Introduce Chákṣu, a novel retinal fundus image database.
  • Facilitate the evaluation of computer-assisted glaucoma prescreening techniques.
  • Provide a resource for developing artificial intelligence-based glaucoma diagnostics.

Main Methods:

  • Compiled 1345 color fundus images from three camera brands.
  • Included expert ophthalmologist annotations for optic disc and optic cup outlines.
  • Generated segmentation ground-truths using mean, median, majority, and STAPLE algorithms.
  • Calculated cup-to-disc ratios and provided image-wise glaucoma decisions.

Main Results:

  • The Simultaneous Truth and Performance Level Estimation (STAPLE) algorithm achieved the highest agreement with expert annotations.
  • Performance indices demonstrated varying levels of agreement for different annotation fusion methods.
  • The database provides detailed annotations crucial for algorithm training and validation.

Conclusions:

  • Chákṣu is the largest Indian-ethnicity-specific fundus image database with expert annotations.
  • The database serves as a valuable resource for advancing AI-driven glaucoma diagnostics.
  • Chákṣu will aid in the development and evaluation of computer-assisted glaucoma prescreening tools.