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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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Folate Pathway Inhibitors, An Underestimated and Underexplored Molecular Target for New Anti-tuberculosis Agents
Sandra Valeria Vassiliades1, Lara Gimenez Borges1, Jeanine Giarolla1
1Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Mini Reviews in Medicinal Chemistry
|February 6, 2023
Summary
The folate metabolic cycle is crucial for cellular replication. New drug targets, including less-explored enzymes in the folate pathway, offer innovative strategies for developing novel antituberculosis agents against resistant strains.
Area of Science:
- Biochemistry
- Microbiology
- Drug Discovery
Background:
- The folate metabolic cycle is vital for cellular homeostasis and replication.
- Key enzymes like dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Mycobacterium tuberculosis (Mtb) have been traditional drug targets.
- Emergence of multidrug-resistant strains necessitates exploration of alternative targets within the folate pathway.
Conclusions:
- Targeting novel enzymes in the Mtb folate metabolic cycle is a promising strategy for new antituberculosis agents.
- Continued research into underexplored enzymes like DHFS and SHMT is crucial for combating drug resistance.
- Innovative inhibitor design and synthetic chemistry are key to developing next-generation anti-TB drugs.
Keywords:
M. tuberculosisThyXantimycobacterialdUMP analogsdihydrofolate synthasedihydropteroate synthaseflavin-dependent thymidylate synthasefolic acidMore Related Videos
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