Rate of Complete Spectacle Independence with a Trifocal Intraocular Lens: A Systematic Literature Review and...

Area of Science:

• Ophthalmology
• Biomaterials Science
• Medical Optics

Background:

• Cataract surgery often requires corrective lenses post-operatively.
• Trifocal intraocular lenses (IOLs) aim to restore vision at multiple distances.
• The AcrySof PanOptix (TFNTXX/TFATXX) is a specific trifocal IOL model.

Purpose of the Study:

• To determine the overall rate of complete spectacle independence after bilateral implantation of the AcrySof PanOptix trifocal IOL.
• To analyze spectacle independence across different working distances (near, intermediate, far).

Main Methods:

• Systematic literature review and meta-analysis of studies published between January 2017 and September 2021.
• Inclusion of published studies and congress presentations.
• Bayesian random-effects meta-analysis to pool spectacle independence rates.

Main Results:

• Nineteen studies were identified; 13 were included in the meta-analysis (N=513 patients).
• The pooled rate of complete spectacle independence was 91.6% (95% credible interval: 86.8-95.9%).
• Spectacle independence rates were 89.6% for near, 96.3% for intermediate, and 95.9% for far vision.

Conclusions:

• The AcrySof PanOptix trifocal IOL provides high rates of complete spectacle independence following cataract surgery.
• Approximately nine out of ten patients can achieve freedom from glasses.
• Trifocal IOLs are effective presbyopia-correcting options for cataract patients seeking spectacle independence.