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Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
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Are We Approaching a Change in Paradigm in PET/CT Imaging of Solid Gastrointestinal (or Digestive) Tract Tumors With

Roberto C Delgado Bolton1, Adriana K Calapaquí Terán2, Ken Herrmann3

  • 1From the Department of Diagnostic Imaging (Radiology) and Nuclear Medicine, University Hospital San Pedro and Centre for Biomedical Research of La Rioja (CIBIR), Logroño, La Rioja.

Clinical Nuclear Medicine
|February 8, 2023
PubMed

Insights

Positron emission tomography (PET) imaging using fibroblast activation protein inhibitor (FAPI) compounds shows promise for diagnosing digestive tumors. These radiolabeled agents offer favorable characteristics for effective PET/CT scans in oncology.

Area of Science:

  • Oncology
  • Radiochemistry
  • Medical Imaging

Background:

  • Fibroblast activation protein (FAP) is a target in cancer diagnostics.
  • Radiolabeled fibroblast activation protein inhibitors (FAPI) are emerging as imaging agents.
  • Digestive tumors represent a significant area for diagnostic advancement.

Approach:

  • Review of recent studies on [68Ga]Ga- and [18F]F-labeled FAPI compounds.
  • Evaluation of PET/CT imaging characteristics.
  • Discussion of clinical applications in digestive oncology.

Key Points:

  • [68Ga]Ga-FAPI and [18F]F-FAPI compounds exhibit excellent properties for PET/CT.
  • These agents show high potential for imaging various digestive tumors.
  • FAPI-PET/CT offers a promising new avenue for cancer diagnosis and management.

Conclusions:

  • FAPI-based PET/CT imaging is a rapidly advancing field.
  • The diagnostic utility of FAPI tracers in digestive tumors is significant.
  • Further clinical research is warranted to fully establish FAPI-PET/CT in routine practice.

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