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Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...

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Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

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Distinct Associations Between Postdischarge Cognitive Change Patterns and 1-year Outcomes in Patients Hospitalized

Fengyu Miao¹, Bin Wang¹, Lihua Zhang¹

¹National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, People's Republic of China; Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, People's Republic of China.

Journal of Cardiac Failure

|February 10, 2023

Summary

Acute heart failure (HF) can cause new-onset cognitive impairment, increasing risks for cardiovascular death and rehospitalization. Monitoring cognition post-discharge is crucial, especially for high-risk patients.

Keywords:

Heart failure cognitive function death rehospitalization

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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Area of Science:

Cardiology
Neuroscience
Gerontology

Background:

Cognitive function patterns post-heart failure (HF) hospitalization are not well understood.
The prognostic implications of cognitive impairment after HF are unknown.
Predictors for new-onset cognitive impairment following HF discharge require further investigation.

Purpose of the Study:

To investigate cognitive function changes in patients after hospital discharge for heart failure (HF).
To determine the prognostic significance of cognitive impairment post-HF.
To identify predictors of new-onset cognitive impairment in HF patients.

Main Methods:

A cohort of 2307 patients hospitalized for HF underwent cognitive testing before discharge and at 1-month follow-up.
New-onset, transient, and persistent cognitive impairment were assessed.
Multivariable analyses identified predictors of new-onset cognitive impairment.

Main Results:

Among patients with normal cognition pre-discharge, 13.8% developed new-onset cognitive impairment at 1 month.
New-onset cognitive impairment was associated with an increased risk of cardiovascular death or HF rehospitalization (HR 1.35).
Older age, female sex, lower education, prior cardiovascular disease, lower health status, and lower Mini-Cog scores predicted new-onset cognitive impairment.

Conclusions:

Acute heart failure significantly impacts short-term cognition.
Patients with new-onset cognitive impairment face elevated risks of adverse outcomes.
Cognitive monitoring is essential for high-risk HF patients post-discharge.