Related Experiment Video

Updated: Aug 10, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the

Woo Ho Lee1, Ga Eul Kim1, Kyung Jin Hong1

  • 1Department of Life Science, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea.

International Journal of Molecular Sciences
|February 11, 2023
PubMed
Summary

Insulin receptor substrate 1 (IRS1) negatively regulates regulatory T (Treg) cells. Overexpressing IRS1 in Treg cells impairs their stability, immunosuppressive function, and ability to maintain immune homeostasis.

Keywords:
Foxp3IRS1Treg cellcolitismTORC1

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