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Environmental estrogens shape disease susceptibility.

Ruiqi Zheng1, Yi Zhang1, Shujun Cheng1

  • 1State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

International Journal of Hygiene and Environmental Health
|February 11, 2023
PubMed
Summary
This summary is machine-generated.

Environmental estrogens disrupt endocrine systems, causing various health issues. Human health risks depend on exposure timing, with sensitive windows influencing outcomes differently than lab studies suggest.

Keywords:
Endocrine disruption chemicalsEnvironmental estrogensEpigeneticsExposure windowMulti-generational effectsTrans-generational effects

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Industrialization has increased environmental exposure to endocrine-disrupting chemicals with estrogenic effects.
  • These environmental estrogens are linked to endocrine, metabolic, neurobehavioral, and reproductive disorders, as well as multi-generational abnormalities.
  • Discrepancies exist between molecular/animal studies and epidemiological findings regarding environmental estrogen risks.

Purpose of the Study:

  • To review sources, toxicity, and mechanisms of environmental estrogens.
  • To examine research on representative environmental estrogens.
  • To discuss monitoring, treatment, and human health risks, balancing lab and epidemiological data.

Main Methods:

  • Literature review of environmental estrogen sources and toxicity.
  • Analysis of molecular mechanisms and carcinogenic pathways.
  • Synthesis of data from laboratory, animal, and epidemiological studies.
  • Evaluation of current monitoring and treatment strategies.

Main Results:

  • Environmental estrogens exhibit diverse toxicities, including endocrine disruption and interference with carcinogenesis.
  • A critical factor influencing health outcomes is the existence of sensitive exposure windows during the human lifespan.
  • Epidemiological data often diverges from laboratory findings, highlighting the complexity of human exposure effects.

Conclusions:

  • Environmental estrogens pose significant health risks, necessitating a nuanced understanding of exposure timing.
  • Reconciling laboratory and epidemiological data is crucial for accurate risk assessment.
  • Effective monitoring and intervention strategies are needed to mitigate exposure and health impacts.