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Updated: Aug 10, 2025
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Iridium-Catalyzed Enantioselective Intermolecular Hydroarylation of 1,1-Disubstituted Alkenes
Kentaro Yamakawa1, Ikumi Nakamura1, Kana Sakamoto1
1Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Sumiyoshi, Osaka 558-8585, Japan.
Abstract:
The catalytic enantioselective hydroarylation of 1,1-disubstituted alkenes proceeded by using a cationic iridium/(R)-binap complex to give the corresponding adducts in high yields with high enantioselectivity. The reaction of arenes substituted with heteroaromatic directing groups proceeded to give the addition products linear-selectively. Methallylamine derivatives were good acceptors to obtain high enantioselectivities. The adduct bearing maleimide moiety was readily transformed into the β-chiral amine derivative without loss of the enantiomeric purity.
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