Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release
Yasuhiko Orita1, Susumu Shimanuki2, Satoshi Okada3
1Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-Ku, Tokyo 152-8550, Japan.
Ultrasonics Sonochemistry
|February 16, 2023
Summary
Researchers developed novel carbon dioxide (CO2)-loaded liposomes for enhanced ultrasound-triggered drug delivery. These advanced liposomes demonstrate significantly higher drug release efficiency compared to conventional methods, paving the way for improved therapies.
Area of Science:
- Biotechnology
- Materials Science
- Drug Delivery Systems
Background:
- Liposomes are investigated as drug carriers for on-demand delivery.
- Current ultrasound-triggered liposome systems exhibit low drug release efficiency.
- Improved acoustic responsiveness in liposomes is needed for effective drug delivery.
Purpose of the Study:
- To synthesize and evaluate carbon dioxide (CO2)-loaded liposomes for superior ultrasound-induced drug release.
- To demonstrate the enhanced acoustic responsiveness of CO2-loaded liposomes compared to conventional liposomes.
- To explore a novel liposome synthesis strategy for improved drug delivery therapies.
Main Methods:
- Synthesized CO2-loaded liposomes using supercritical CO2 under high pressure.
- Irradiated liposomes with ultrasound at 237 kHz.
- Quantified drug release efficiency using fluorescent drug models.
- Compared release efficiency with liposomes synthesized via the conventional Bangham method.
Main Results:
- CO2-loaded liposomes synthesized using supercritical CO2 showed 17.1 times higher drug release efficiency.
- CO2-loaded liposomes synthesized using supercritical CO2 and monoethanolamine exhibited 19.8 times higher release efficiency.
- Ultrasound irradiation was performed under human-safe acoustic pressure conditions.
Conclusions:
- CO2-loaded liposomes synthesized via supercritical CO2 exhibit significantly enhanced acoustic responsiveness.
- This novel synthesis strategy offers a promising alternative for on-demand drug release therapies using ultrasound.
- The findings support the development of advanced liposome carriers for future therapeutic applications.
