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Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
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Collagen-Based Biomaterials for Tissue Engineering.

Yiyu Wang1, Zhengke Wang2,3, Yan Dong1

  • 1Department of Prosthodontics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China.

ACS Biomaterials Science & Engineering
|February 17, 2023
PubMed
Summary
This summary is machine-generated.

This review summarizes collagen-based biomaterials for tissue engineering, focusing on bone, cartilage, skin, dental, neuron, cornea, and urological regeneration. It highlights progress and future directions for these versatile regenerative materials.

Keywords:
biomaterialsbiomedical applicationscollagentissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Collagen is a biocompatible regenerative material widely used in biomedical applications.
  • Existing reviews cover collagen sources, structures, properties, and modifications, but not specifically for tissue engineering.
  • Collagen-based biomaterials offer versatile applications due to tunable properties via hybridization and cross-linking.

Purpose of the Study:

  • To provide a comprehensive review of collagen-based biomaterials for tissue regeneration applications.
  • To focus on the utilization of collagen in bone, cartilage, skin, dental, neural, corneal, and urological tissue engineering.
  • To offer insights and practical techniques for future development and identify challenges.

Main Methods:

  • Literature review of collagen-based biomaterials in tissue engineering.
  • Analysis of collagen's role in various regenerative applications.
  • Discussion of current progress, challenges, and future directions.

Main Results:

  • Collagen is extensively utilized in diverse tissue engineering applications.
  • Hybridization and cross-linking strategies enhance collagen's suitability for specific biomedical needs.
  • The review consolidates information on collagen's application across multiple organ systems.

Conclusions:

  • Collagen-based biomaterials are crucial for advancing tissue regeneration.
  • Further research is needed to overcome challenges and optimize collagen for enhanced therapeutic outcomes.
  • This review serves as a guide for developing next-generation collagen-based regenerative therapies.