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Chalcogen Bonding Catalysis with Phosphonium Chalcogenide (PCH).

Zhiguo Zhao1, Yao Wang1

  • 1School of Chemistry and Chemical Engineering, Key Laboratory of the Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, China.

Accounts of Chemical Research
|February 21, 2023
PubMed
Summary
This summary is machine-generated.

Phosphonium chalcogenide (PCH) catalysts enable novel chalcogen bonding catalysis, including dual and chalcogen···π modes. This approach activates hydrocarbons and solves challenging reactivity and selectivity issues in organic synthesis.

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Area of Science:

  • Organic Synthesis
  • Supramolecular Chemistry
  • Catalysis

Background:

  • Sustainable organic synthesis requires innovative catalysis.
  • Chalcogen bonding catalysis is an emerging field addressing reactivity and selectivity challenges.
  • Phosphonium chalcogenides (PCH) are potent catalysts for chalcogen bonding.

Purpose of the Study:

  • To present progress in chalcogen bonding catalysis using PCH.
  • To explore new catalytic modes like chalcogen-chalcogen and chalcogen···π bonding.
  • To demonstrate PCH's ability to activate hydrocarbons and solve synthetic problems.

Main Methods:

  • Systematic study of PCH catalysts' properties and structure-activity relationships.
  • Development and application of chalcogen-chalcogen bonding and chalcogen···π bonding catalysis.
  • Investigation of dual chalcogen bonding catalysis for complex reactions.

Main Results:

  • Discovery of PCH as efficient chalcogen bonding catalysts.
  • Successful implementation of chalcogen-chalcogen bonding for heterocycle synthesis and Se···O bonding for calixpyrrole synthesis.
  • Demonstration of chalcogen···π bonding for alkene activation, coupling, and cyclization, including challenging cross-coupling reactions.

Conclusions:

  • PCH catalysts offer a versatile platform for diverse organic transformations.
  • Chalcogen bonding catalysis with PCH overcomes limitations of traditional methods.
  • This work provides significant solutions for complex synthetic challenges.