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Chalcogen···π Bonding Catalysis: Concept, Reaction Development and Emerging Opportunities.

Haofu Zhu¹, Hang Zhou¹, Yao Wang¹

¹School of Chemistry and Chemical Engineering, Shandong University, Jinan, P. R. China.

Chemistry, an Asian Journal

|June 10, 2026

Summary

This summary is machine-generated.

Chalcogen···π (Ch···π) interactions, once overlooked, are now a powerful catalytic platform for π-systems. This review explores their use in achieving previously unattainable chemical transformations.

Keywords:

catalyst design chalcogen···π interactions noncovalent interactions organocatalysis σ‐hole

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Area of Science:

Chemistry
Organic Chemistry
Catalysis

Background:

Noncovalent interactions activating π-systems were historically disfavored.
Recent research highlights chalcogen···π (Ch···π) interactions as a robust catalytic approach.
Ch···π interactions enable diverse transformations of π-systems.

Purpose of the Study:

To review the emerging field of chalcogen···π interactions in catalysis.
To discuss catalyst design, mechanistic insights, and strategies.
To highlight the unique capabilities of Ch···π interactions.

Main Methods:

Review of recent literature on Ch···π interactions.
Analysis of catalyst design principles.
Discussion of mechanistic pathways.
Categorization of catalytic strategies.

Main Results:

Ch···π interactions offer a reliable platform for catalyzing reactions involving π-systems.
These interactions enable reactions not achievable through other methods.
Both pure and cooperative Ch···π interactions are effective.

Conclusions:

Chalcogen···π interactions represent a significant advancement in catalysis.
This approach provides novel strategies for chemical synthesis.
Further exploration of Ch···π interactions is warranted.