Related Experiment Video
Updated: Aug 9, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Oral Lesions Associated with Systemic Disease
Jasbir D Upadhyaya1, Vimi Sunil Mutalik2
1Department of Applied Dental Medicine, Southern Illinois University School of Dental Medicine, 2800 College Avenue, Building 285, Alton, IL 62002, USA.
Oral manifestations can signal systemic diseases, prompting early detection by healthcare providers. This review aids clinicians in diagnosing diverse oral lesions linked to systemic conditions for timely intervention.
Area of Science:
- Oral Medicine
- Dermatology
- Internal Medicine
Background:
- Oral manifestations are often the initial clinical sign of underlying systemic diseases.
- Oral health professionals play a crucial role in the early identification of these signs.
- Lesions can be characteristic, aiding early detection, or diverse, necessitating comprehensive evaluation.
Purpose of the Study:
- To review oral manifestations of select systemic diseases.
- To assist clinicians in developing differential diagnoses for oral lesions.
- To facilitate early diagnosis and timely intervention for patients with systemic conditions.
Main Methods:
- Literature review of oral manifestations associated with systemic diseases.
- Compilation of characteristic clinical features of select oral lesions.
- Discussion of diagnostic approaches for diverse oral manifestations.
Main Results:
- Systemic diseases frequently present with distinct oral manifestations.
- Early recognition of specific oral lesions can indicate underlying systemic illness.
- A broad range of clinical presentations requires a systematic diagnostic process.
Conclusions:
- Oral health care providers are pivotal in identifying systemic diseases through oral signs.
- Understanding oral manifestations aids in differential diagnosis and prompt patient management.
- Timely intervention based on early oral diagnosis can significantly impact patient outcomes.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Chronic Kidney Disease II: Clinical Manifestations
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:

