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Related Experiment Video

Updated: Aug 9, 2025

Isolation, Processing and Analysis of Murine Gingival Cells

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

Plasma Cell Gingivitis and Its Mimics.

Rania H Younis¹, Maria Georgaki², Nikolaos G Nikitakis²

¹Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, 650 West Baltimore Street, 7th floor suite 7257, Baltimore, MD 21201, USA.

Oral and Maxillofacial Surgery Clinics of North America

|February 22, 2023

Summary

Plasma cell gingivitis (PCG) is an oral inflammatory condition. It is likely caused by hypersensitivity reactions to oral antigens and requires specific diagnosis to differentiate from other lesions.

Keywords:

Clinical features Differential diagnosis Histologic features Plasma cell gingivitis Treatment

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Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

Area of Science:

Oral pathology
Dermatology
Immunology

Background:

Plasma cell gingivitis (PCG) is an inflammatory condition affecting oral mucosa.
Characterized by dense plasma cell infiltrate, PCG lesions resist standard prophylactic treatments.
The etiology is often linked to hypersensitivity to oral antigens like toothpaste or spices.

Purpose of the Study:

To outline the characteristics of Plasma Cell Gingivitis.
To emphasize the diagnostic challenges and differential diagnoses for PCG.
To highlight the importance of clinicopathologic correlation and patch testing.

Main Methods:

Review of clinical and pathological features of PCG.
Discussion of differential diagnoses including reactive, granulomatous, and neoplastic lesions.
Emphasis on patient history and clinicopathologic correlation for diagnosis.

Main Results:

PCG presents as an inflammatory condition unresponsive to prophylactic care.
Hypersensitivity to oral antigens is the most probable cause.
Accurate diagnosis requires ruling out other oral lesions through thorough workup.

Conclusions:

Plasma cell gingivitis necessitates a specific diagnostic approach beyond routine care.
Identifying the causative antigen through patch testing can be crucial for chronic cases.
Distinguishing PCG from mimics is essential for effective patient management.