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Related Concept Videos

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)01:19

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

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Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...
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Chirality at Nitrogen, Phosphorus, and Sulfur02:30

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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
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NMR Spectroscopy: Spin–Spin Coupling01:08

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The spin state of an NMR-active nucleus can have a slight effect on its immediate electronic environment. This effect propagates through the intervening bonds and affects the electronic environments of NMR-active nuclei up to three bonds away; occasionally, even farther. This phenomenon is called spin–spin coupling or J-coupling. Coupling interactions are mutual and result in small changes in the absorption frequencies of both nuclei involved. While nuclei of the same element are involved...
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¹H NMR: Interpreting Distorted and Overlapping Signals01:02

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Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
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Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
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Spin-Controlled Helical Quantum Sieve Chiral Spectrometer.

Arnab Maity1, Yael Hershkovitz-Pollak1, Ritu Gupta2

  • 1Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.

Advanced Materials (Deerfield Beach, Fla.)
|February 22, 2023
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Summary
This summary is machine-generated.

A novel molecular-spin-sensitive-antenna (MSSA) enables portable detection of chiral molecules. This technology uses AI for accurate, real-time analysis, safeguarding health and the environment.

Keywords:
Rashbachiralgrapheneneuromorphicspectrometryspinspintronics

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Chiral molecules exist as enantiomers with distinct biological and environmental impacts.
  • Accurate and portable detection methods for chiral enantiomers are crucial for risk assessment and monitoring.
  • Current analytical techniques often lack the speed, portability, or selectivity required for real-time applications.

Purpose of the Study:

  • To develop a molecular-spin-sensitive-antenna (MSSA) for spatiotemporal identification of chiral enantiomers.
  • To integrate MSSA technology with artificial intelligence for enhanced detection and classification capabilities.
  • To demonstrate the potential of MSSA for portable, wearable, and real-time analysis of chiral molecules.

Main Methods:

  • Fabrication of MSSA using functionalized graphene on a cellulose network.
  • Incorporation of a helical quantum sieve for chiral trapping and separation.
  • Utilizing a spin-sensitive center and chirality-induced-spin mechanism for enantiomeric recognition.
  • Applying neuromorphic artificial intelligence for decision-making and classification.

Main Results:

  • MSSA structures demonstrated effective chiral trapping and recognition.
  • The integrated system achieved 95-98% accuracy in detecting and classifying pure and mixed chiral molecules (e.g., butanol, limonene, xylene isomers).
  • The developed spectrometry is fast, portable, and wearable.

Conclusions:

  • The MSSA approach offers a powerful new tool for the detection and classification of chiral molecules.
  • This technology has significant implications for environmental monitoring and human health risk assessment.
  • MSSA serves as a dynamic monitoring tool throughout the chiral molecule lifecycle.