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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Aug 9, 2025

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Using Finite Element Modeling in Bone Mechanoadaptation.

Quentin A Meslier¹, Sandra J Shefelbine^2,3

¹Department of Bioengineering, Northeastern University, 334 Snell, 360 Huntington Ave, Boston, MA, USA.

Current Osteoporosis Reports

|February 22, 2023

Summary

This summary is machine-generated.

Finite element modeling (FEM) analyzes bone adaptation to mechanical forces. This review explores how FEM aids in understanding bone mechanoadaptation and designing future treatments.

Keywords:

Bone Finite element model Mechanoadpatation

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Last Updated: Aug 9, 2025

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Area of Science:

Biomechanics
Orthopedics
Computational Biology

Background:

Bone tissue exhibits mechanoadaptation, altering structure and properties based on mechanical environment.
Finite element modeling (FEM) has been instrumental for 50 years in studying bone's response to mechanical loading.

Purpose of the Study:

To review the application of finite element modeling in the context of bone mechanoadaptation.
To highlight the role of FEM in understanding bone geometry, material properties, and mechanical loading.

Main Methods:

Review of existing literature on finite element modeling in bone mechanoadaptation research.
Analysis of how FEM complements experimental and clinical observations.

Main Results:

FEM estimates complex mechanical stimuli at tissue and cellular levels.
FEM aids in explaining experimental findings and designing loading protocols and prosthetics.
The complexity of FEM should be tailored to the research question.

Conclusions:

Finite element modeling is a powerful tool for studying bone adaptation.
Advancements in imaging and computation will enhance FEM's utility.
FEM is expected to contribute to designing treatments for bone pathologies leveraging mechanoadaptation.