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Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
Jianping Shi1,2, Fuyin Wei1, Bilal Chouraki1
1School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210046, China.
Biomimetics (Basel, Switzerland)
|February 22, 2023
Summary
Optimizing 3D bioprinted tissues with vascular networks enhances cell viability. Simulations of 3D TPMS vascular models guided in vitro perfusion culture, improving nutrient delivery and waste removal for tissue engineering.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Regenerative Medicine
Background:
- 3D bioprinted tissues offer alternatives to animal models in drug testing and clinical trials.
- Ensuring nutrient and oxygen supply to internal cells in biomimetic tissues is critical for viability.
- Vascular flow channels are essential for nutrient diffusion, cell growth, and waste removal in engineered tissues.
Purpose of the Study:
- To develop and simulate a 3D TPMS vascular flow channel network model.
- To analyze the impact of perfusion pressure on blood flow rate and channel wall pressure.
- To optimize in vitro perfusion culture parameters for improved biomimetic tissue structures.
Main Methods:
- Development of a 3D Triply Periodic Minimal Surface (TPMS) vascular flow channel network model.
- Computational simulation to analyze fluid dynamics under varying perfusion pressures.
- Optimization of perfusion culture parameters based on simulation results.
Main Results:
- Simulation revealed the relationship between perfusion pressure, blood flow rate, and channel wall pressure.
- Identified optimal perfusion pressure ranges to ensure adequate fluid distribution.
- Demonstrated the potential to avoid perfusion failure and cell necrosis through parameter optimization.
Conclusions:
- The developed 3D TPMS model and simulations aid in optimizing vascularized tissue engineering.
- Proper control of perfusion pressure is crucial for maintaining cell viability and tissue function.
- This research advances in vitro culture techniques for developing functional biomimetic tissues.
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