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Microfluidic Fabrication of Natural Polymer-Based Scaffolds for Tissue Engineering Applications: A Review
Elisabetta Rosellini1, Maria Grazia Cascone1
1Department of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56122 Pisa, Italy.
Biomimetics (Basel, Switzerland)
|February 22, 2023
Summary
Microfluidic techniques offer advanced methods for creating natural polymer scaffolds for tissue engineering. These methods overcome limitations of traditional approaches, enabling precise control over scaffold structure and properties.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Microfluidics
Background:
- Natural polymers are ideal for tissue engineering scaffolds due to biocompatibility and biomimicry.
- Traditional scaffold fabrication methods suffer from limitations like solvent use, non-uniform structures, and poor pore interconnectivity.
Purpose of the Study:
- To review microfluidic fabrication techniques for natural polymer-based microparticles, microfibers, and 3D scaffolds.
- To highlight the advantages of microfluidics over traditional methods in tissue engineering.
Main Methods:
- Utilizing droplet microfluidics and microfluidic spinning for scaffold fabrication.
- Focusing on natural polymers as primary material source.
Main Results:
- Microfluidics enables the production of uniform microparticles and microfibers.
- Achieves precise control over scaffold geometry, pore size, and interconnectivity.
- Presents microfluidics as a potentially cheaper manufacturing technique.
Conclusions:
- Microfluidic fabrication offers superior control and uniformity for natural polymer scaffolds in tissue engineering.
- These advanced scaffolds hold significant promise for various tissue regeneration applications.
