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Updated: Aug 9, 2025

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice
Published on: October 4, 2014
Stroke volume variation does not correlate with central venous pressure during hepatectomy
Pablo Parra-Membrives1, José M Lorente-Herce2, Granada Jiménez-Riera1
1Associate Professor of the Department of Surgery, University of Seville, Spain; Hepatobiliary and Pancreatic Surgery Unit of the General and Digestive Surgery Department, Valme University Hospital, Sevilla, Spain.
Central venous pressure (CVP) monitoring is standard in liver surgery. However, this study found stroke volume variation (SVV) does not correlate with CVP, indicating SVV cannot replace CVP for safe hepatectomy.
Area of Science:
- Anesthesiology
- Surgical Monitoring
- Hepatobiliary Surgery
Background:
- Central venous pressure (CVP) measurement is the standard for monitoring patients during hepatectomy to maintain low pressure and minimize blood loss.
- Stroke volume variation (SVV) has emerged as a potential tool for monitoring preload and guiding fluid replacement in liver surgery.
Purpose of the Study:
- To determine if SVV correlates with CVP values during liver resection.
- To assess if SVV can replace CVP measurement in hepatectomy procedures.
Main Methods:
- 30 patients undergoing 32 liver resections were included between January 2021 and February 2022.
- Paired CVP and SVV data were collected every 10 minutes throughout the surgeries.
- Correlation analysis was performed, stratified by surgical approach, hilar clamping, operative timing, and PEEP values.
Main Results:
- A total of 519 paired SVV/CVP values were recorded.
- A very weak negative correlation was detected between SVV and CVP (Pearson coefficient -0.122, p=0.005).
- Stratified analysis confirmed no significant correlation between SVV and CVP under various surgical conditions.
Conclusions:
- CVP and SVV values show no relevant correlation during liver surgery.
- CVP measurement remains valuable and should not be replaced by SVV monitoring for safe hepatectomy.
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