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Updated: Aug 9, 2025
11:18
Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
7.4K
Advanced Drug Delivery Systems for Renal Disorders
Batoul Alallam1, Hazem Choukaife2, Salma Seyam1
1Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Penang, Malaysia.
Gels (Basel, Switzerland)
|February 24, 2023
Summary
Nanotechnology offers novel solutions for kidney disease treatment by overcoming the glomerular filtration barrier. Nanomaterials show promise for targeted drug delivery, improving therapeutic outcomes for renal illnesses.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Nephrology
Background:
- Kidney diseases pose a significant global health challenge.
- The renal glomerulus acts as a barrier, hindering effective drug delivery to kidneys.
- Current therapies often fail due to poor drug distribution in renal illnesses.
Purpose of the Study:
- To review the potential of nanotechnology in improving drug delivery to the kidneys.
- To highlight nanomaterials and nanosystems for overcoming renal drug delivery barriers.
- To discuss kidney-targeted drug delivery strategies and common sites.
Main Methods:
- Review of current literature on nanotechnology in renal therapy.
- Analysis of physicochemical properties of nanomaterials for drug delivery.
- Discussion of various nanosystems, including nanoparticles and hydrogels.
- Examination of kidney-targeted delivery strategies and sites.
Main Results:
- Nanomaterials possess unique properties (size, charge, surface) beneficial for renal therapy.
- Nanosystems demonstrate potential for enhanced drug distribution and pharmacokinetics in kidneys.
- Nanoparticles and hydrogels are key components in overcoming glomerular barriers.
- Various strategies exist for targeting drug delivery to specific kidney sites.
Conclusions:
- Nanotechnology presents a promising avenue for advancing kidney disease treatment.
- Targeted drug delivery systems using nanomaterials can improve therapeutic efficacy.
- Further research into nanomedicine is crucial for overcoming challenges in renal drug delivery.
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