Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

153
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
153
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

61
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
61
Antibiotic Selection00:57

Antibiotic Selection

54.9K
Overview
54.9K
Bacterial Signaling01:30

Bacterial Signaling

33.4K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
33.4K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

56
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
56
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

56
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
56

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure of core assembly of the Clostridioides difficile germinosome.

Nature communications·2026
Same author

A Lactone-Enabled Approach to Metronidazole-Based Scaffolds.

The Journal of organic chemistry·2026
Same author

Outer Membrane-Peptidoglycan Anchoring in <i>Pseudomonas aeruginosa</i>.

Journal of the American Chemical Society·2026
Same author

A Concise Route to Orthogonally Protected Bulgecinine.

The Journal of organic chemistry·2025
Same author

In Recognition of the 80th Anniversary of Nobel Prize for Discovery of Penicillin: Call for Papers for a Special Issue.

ACS infectious diseases·2025
Same author

Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of <i>Streptococcus pneumoniae</i> Penicillin-Binding Protein 2x.

Journal of medicinal chemistry·2025
Same journal

Correction: Assalve et al. Marine Algal Metabolites as Cellular Antioxidants: A Study of Caulerpin and Caulerpinic Acid in <i>Saccharomyces cerevisiae</i>. <i>Mar. Drugs</i> 2025, <i>23</i>, 338.

Marine drugs·2026
Same journal

Laurinterol, the Main <i>Smart Secondary Metabolite</i> Among Lauranes and Cyclolauranes.

Marine drugs·2026
Same journal

Red Light Enhances Biomass and Bioactive Compounds Through Photosynthetic Acclimation in <i>Anabaena variabilis</i>.

Marine drugs·2026
Same journal

Seaweed-Derived Extract Targets Porphyr'ageing to Modulate the Visible Signs of Aging in Human Skin.

Marine drugs·2026
Same journal

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

Marine drugs·2026
Same journal

Amylimycins A-C, New Bacillomycin D Analogs from Marine-Derived <i>Bacillus amyloliquefaciens</i>.

Marine drugs·2026
See all related articles

Related Experiment Video

Updated: Aug 9, 2025

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

10.5K

β-Lactams from the Ocean.

Jed F Fisher1, Shahriar Mobashery1

  • 1Department of Chemistry & Biochemistry, 354 McCourtney Hall, University of Note Dame, Notre Dame, IN 46656-5670, USA.

Marine Drugs
|February 24, 2023
PubMed
Summary
This summary is machine-generated.

Marine environments may harbor fewer beta-lactam antibiotics due to structural similarities with quorum sensing molecules. This presents an opportunity for discovering novel marine natural products and enzyme targets.

Keywords:
AHL, N-acylhomoserine lactonePBP, penicillin-binding proteinenzyme inhibitorsquorum quenchingsalinosporamideβ-lactonase

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

6.6K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.5K

Related Experiment Videos

Last Updated: Aug 9, 2025

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

10.5K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

6.6K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.5K

Area of Science:

  • Marine Natural Products Chemistry
  • Medicinal Chemistry
  • Microbial Biochemistry

Background:

  • Beta-lactam antibiotics (penicillins, cephalosporins, carbapenems) are vital secondary metabolites from terrestrial microbes, crucial for inhibiting bacterial cell-wall synthesis.
  • Beta-lactamases, enzymes that degrade beta-lactams, are also medically significant, leading to the development of inhibitors.
  • The scarcity of beta-lactam ring structures in marine natural products is notable despite their medical importance.

Purpose of the Study:

  • To explore potential reasons for the limited discovery of marine-derived beta-lactam secondary metabolites.
  • To propose a hypothesis linking the structural similarity of beta-lactams to beta-lactones involved in microbial quorum sensing.
  • To identify opportunities for discovering novel bioactive marine compounds and enzyme targets.

Main Methods:

  • Comparative structural analysis of beta-lactam antibiotics and beta-lactones involved in quorum sensing.
  • Hypothesizing ecological roles and evolutionary pressures in marine environments.
  • Literature review on marine natural products and microbial signaling.

Main Results:

  • Beta-lactams and beta-lactones share steric and reactivity similarities.
  • This structural overlap may compromise the ecological advantage of beta-lactams in marine microbial communities.
  • The similarity suggests a potential for cross-reactivity or interference with quorum sensing pathways.

Conclusions:

  • The structural mimicry between beta-lactams and quorum sensing beta-lactones may explain their rarity in marine environments.
  • This presents a novel avenue for drug discovery, focusing on marine organisms and their unique chemical ecology.
  • Investigating these structural similarities can lead to the identification of new enzyme targets and biologically active compounds.