A Mathematical Model for Determining the Body's Fluctuating Need for and Synthesis of Active Vitamin D

The process by which 1,25(OH)₂D₃ is synthesized and degraded and how it is transported out of the cell and body is described. The changing demand for the synthesis of 1-25(OH)₂D₃ during different conditions experienced by the body is reviewed. A method of determining 1,25(OH)₂D₃ synthesis and demand, and the percent utilization of 25(OH)D₃ to make 1,25(OH)₂D₃ is presented based on the measurement of the end metabolites of 1,25(OH)₂D₃ and of its immediate precursor, 25(OH)D₃. A mathematical model has been developed to allow the calculation of 1,25(OH)₂ D synthesis, and demand, and the percent utilization of 25(OH)D₃. Simple algebraic equations have been derived which allow the calculation of these new parameters using the concentrations of the end metabolites of 1,25(OH)₂D₃ and its immediate precursor, 25(OH)D₃ in the serum and urine. Vitamin D plays an important role in combating invading bacteria and viruses and in subduing the body's associated inflammatory response. This new approach to evaluating vitamin D status may help clinicians determine 25(OH)D₃ and 1,25(OH)₂D₃ levels needed to suppress bacterial infections, viral replication during new viral infections and the reactivation of latent viruses, and to downregulate the inflammatory responses caused by bacteria and viruses.