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Microfluidic Chip Fabrication and Method to Detect Influenza
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Ultrafast Nucleic Acid Detection Equipment with Silicon-Based Microfluidic Chip.

Jiali Zhang1,2, Zhuo Yang1,2, Liying Liu3

  • 1School of Microelectronics, Shanghai University, Shanghai 201800, China.

Biosensors
|February 25, 2023
PubMed
Summary

This study presents an ultrafast polymerase chain reaction (PCR) device for rapid virus detection. The portable equipment can identify viruses in just 5 minutes, aiding infectious disease prevention.

Keywords:
microfluidic Chipnucleic acid amplification detectionpolymerase chain reaction (PCR)ultrafast PCR equipment

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Area of Science:

  • Biotechnology
  • Medical Diagnostics
  • Infectious Disease Research

Background:

  • Emerging infectious diseases like COVID-19, monkeypox, and Ebola necessitate rapid diagnostic tools.
  • Current diagnostic methods can be time-consuming, hindering effective epidemic control.

Purpose of the Study:

  • To design and develop an ultrafast polymerase chain reaction (PCR) equipment for rapid virus detection.
  • To improve upon existing diagnostic technologies for enhanced efficiency and portability.

Main Methods:

  • Development of a silicon-based PCR chip with optimized thermal and fluid dynamics.
  • Integration of a thermoelectric cooler (TEC) and a PID controller for accelerated thermal cycling.
  • Incorporation of an optical detection module capable of identifying two fluorescent molecules.

Main Results:

  • The equipment successfully performs 40 PCR amplification cycles in 5 minutes.
  • The system supports simultaneous testing of up to four samples.
  • The developed PCR equipment is portable, user-friendly, and cost-effective.

Conclusions:

  • The ultrafast PCR equipment offers a significant advancement in rapid virus detection capabilities.
  • Its portability and speed show great potential for effective epidemic prevention and control.
  • This technology can be a valuable tool in managing future infectious disease outbreaks.