Related Experiment Video
Updated: Aug 9, 2025
04:50
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
291
Outcomes of Prospectively Followed Pregnancies in Rheumatoid Arthritis: A Multicenter Study from Romania.
Anca Bobircă1,2, Anca Angela Simionescu3, Anca Emanuela Mușetescu4
1Department of Internal Medicine and Rheumatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Life (Basel, Switzerland)
|February 25, 2023
Summary
Women with rheumatoid arthritis (RA) face higher adverse pregnancy outcomes (APO). Planned pregnancies and low-dose corticosteroids significantly reduce APO risk in RA patients.
Area of Science:
- Rheumatology
- Obstetrics
- Reproductive Health
Background:
- Women with rheumatoid arthritis (RA) may have an increased risk of adverse pregnancy outcomes (APO).
- Understanding these risks is crucial for managing pregnancies in RA patients.
Purpose of the Study:
- To compare pregnancy outcomes in RA patients versus the general obstetric population (GOP).
- To identify risk profiles and protective factors for APO in RA pregnancies.
Main Methods:
- A case-control study involving 82 pregnancies in RA patients and 299 in the GOP.
- Prospective follow-up of pregnancies to assess outcomes.
Main Results:
- RA patients experienced a 41.5% APO rate, including higher risks of spontaneous abortion, preterm delivery, and small for gestational age infants compared to GOP.
- Maternal age over 35 was a significant risk factor for APO (OR=5.59).
- Planned pregnancies (OR=0.12) and daily corticosteroid use ≤10 mg (OR=0.19) were protective factors against APO.
Conclusions:
- Rheumatoid arthritis pregnancies are associated with increased adverse outcomes.
- Pregnancy planning and judicious corticosteroid use can mitigate risks for RA patients.
Related Concept Videos
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
43
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
43
01:11Genome-wide Association Studies-GWAS
13.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.8K
01:21Rheumatic Heart Disease III: Medical Management
24
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
24
01:23Rheumatic Heart Disease I: Introduction
25
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
25
01:20Rheumatic Heart Disease IV: Nursing Management
28
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
28