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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
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Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Modified Bacteriophage for Tumor Detection and Targeted Therapy.

Yuanzhao Shen1,2,3, Jingyu Wang1, Yuting Li1

  • 1College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, China.

Nanomaterials (Basel, Switzerland)
|February 25, 2023
PubMed
Summary
This summary is machine-generated.

Genetically engineered bacteriophages (phages) show promise for detecting tumor antigens and as anti-tumor reagents. Modified phages offer new avenues for cancer diagnosis and targeted therapy.

Keywords:
bacteriophage (phage)biological detectionchemical modificationgenetically engineered phagesphage displaytargeted therapytumor screening

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Area of Science:

  • Biotechnology
  • Oncology
  • Virology

Background:

  • Malignant tumors are a major global health concern.
  • Bacteriophages (phages) are bacterial viruses with potential biomedical applications.
  • Genetic and chemical modifications enhance phage capabilities for cancer research.

Purpose of the Study:

  • To review recent advancements in engineered and modified phages for tumor diagnosis and therapy.
  • To explore the advantages and limitations of using modified phages in oncology.
  • To suggest practical applications for modified phages in clinical settings.

Main Methods:

  • Review of studies on genetically engineered phages for tumor antigen detection.
  • Analysis of chemically modified phages for targeted cancer therapy.
  • Investigation of phage-nanoparticle composites for enhanced biological detection and treatment.

Main Results:

  • Engineered phages can serve as probes for detecting tumor-specific antigens.
  • Modified phages demonstrate potential as anti-tumor therapeutic agents.
  • Phage-nanoparticle conjugates expand applications in diagnostics and therapeutics.

Conclusions:

  • Modified phages represent a versatile platform for cancer diagnosis and targeted therapy.
  • Understanding the advantages and limitations is crucial for clinical translation.
  • Specific application scenarios can be identified based on phage modification strategies.