Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment.

ACS nano·2026
Same author

Ultrasonic-Assisted Photocatalytic Conversion of Air to Nitric Acid Under Ambient Conditions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Influencing Factors and Optimization Strategies of Bioinert Materials in the Process of Osseointegration.

ACS biomaterials science & engineering·2025
Same author

Application and Perspectives: Magnesium Materials in Bone Regeneration.

ACS biomaterials science & engineering·2024
Same author

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies.

APL bioengineering·2024
Same author

Advances in NIR-Responsive Natural Macromolecular Hydrogel Assembly Drugs for Cancer Treatment.

Pharmaceutics·2023

Related Experiment Video

Updated: Aug 8, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K

The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering.

Ziyi Feng1, Xin Su1, Ting Wang1

  • 1Department of Plastic Surgery, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang 110002, China.

Pharmaceutics
|February 25, 2023
PubMed
Summary

Bone tissue engineering faces challenges with traditional grafts. A novel "bottom-up" approach using microspheres offers a flexible solution for bone defect repair and cell delivery.

Keywords:
anti-inflammatorybone tissue engineeringendochondral ossificationmicrospheresorganoid

More Related Videos

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
05:21

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

3.0K
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

9.9K

Related Experiment Videos

Last Updated: Aug 8, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
05:21

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

3.0K
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

9.9K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Regenerative Medicine

Background:

  • Bone defects present significant global healthcare and economic challenges.
  • Traditional bone grafting methods have limitations, driving the need for advanced bone tissue engineering solutions.
  • Current bone tissue engineering approaches lack flexibility and optimal nutrient delivery for cells within scaffolds.

Purpose of the Study:

  • To introduce a novel
  • bottom-up
  • fabrication strategy for bone tissue engineering.
  • To explore the potential of microspheres as adaptable scaffolds and drug delivery systems for bone regeneration.
  • To review and analyze strategies for microsphere production, material classification, and drug loading in bone tissue engineering.

Main Methods:

  • Review of various microsphere production strategies.
  • Classification of raw materials for microsphere fabrication.
  • Analysis of drug loading techniques within microspheres.
  • Examination of new applications of microspheres in bone tissue engineering.

Main Results:

  • Microspheres (1-1000 µm) offer a versatile platform for cell support in bone tissue engineering.
  • The
  • bottom-up
  • method using microspheres provides enhanced flexibility and adaptability to defect shapes.
  • Microspheres can function as both scaffolds for cell growth and sophisticated drug delivery systems.

Conclusions:

  • Microsphere-based strategies represent a promising advancement in bone tissue engineering.
  • Further research into microsphere production and application can overcome limitations of traditional bone grafts.
  • This approach holds potential for improved bone defect treatment and regenerative therapies.