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Reproducibility of cerebral perfusion measurements using BOLD delay.

Ahmed A Khalil1,2,3,4, Ayse C Tanritanir1, Ulrike Grittner4,5

  • 1Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Human Brain Mapping
|February 25, 2023
PubMed
Summary

Blood-Oxygen-Level-Dependent (BOLD) delay offers a noninvasive way to measure cerebral perfusion. This study found BOLD delay to be reproducible, especially in posterior brain regions, supporting its use in longitudinal monitoring.

Keywords:
BOLD delayblood flowperfusionreproducibilityresting-state functional MRI

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Area of Science:

  • Neuroimaging
  • Cerebrovascular Physiology
  • Medical Imaging Techniques

Background:

  • Blood-Oxygen-Level-Dependent (BOLD) delay is an emerging noninvasive technique for assessing cerebral perfusion.
  • Unlike contrast-enhanced methods, BOLD delay avoids intravenous agents, making it suitable for repeated longitudinal monitoring.

Purpose of the Study:

  • To evaluate the reproducibility of BOLD delay measurements.
  • To identify factors influencing BOLD delay reproducibility in subjects with normal cerebral perfusion.

Main Methods:

  • Reproducibility assessed using data from 136 subjects scanned twice.
  • Varied scanners, sequence parameters, and inter-scan intervals across subjects.
  • Linear mixed models and intraclass correlation coefficients used for analysis.

Main Results:

  • BOLD delay demonstrated good overall reproducibility.
  • Highest reproducibility observed in the posterior cerebral artery territory.
  • Mean test-retest difference was 1.2 seconds (95% CI: 1.0–1.4 s) after accounting for influencing factors.

Conclusions:

  • BOLD delay is a reproducible method for assessing cerebral perfusion.
  • Longitudinal interpretation of BOLD delay requires caution, particularly for small changes or in specific brain regions.