Multifunctional 3D platforms for rapid hemostasis and wound healing: Structural and functional prospects at...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing Technologies

Background:

• Chronic blood loss and impaired wound healing necessitate advanced hemostatic materials.
• Recent innovations focus on multifunctional hemostats for accelerated tissue repair and regeneration.

Purpose of the Study:

• To review three-dimensional (3D) hemostatic platforms fabricated using cutting-edge technologies.
• To critically analyze the role of micro/nano-3D topography and biomaterial properties in hemostasis and healing.
• To highlight the advantages and limitations of current 3D hemostats for future tissue engineering.

Main Methods:

• Overview of fabrication techniques including electrospinning, 3D printing, and lithography.
• Analysis of micro/nano-3D topographical features and biomaterial characteristics.
• Discussion of hemostat-biointerface interactions for clot formation and healing.

Main Results:

• 3D hemostatic platforms demonstrate potential for rapid blood clot formation.
• Micro/nano-topography and specific biomaterial properties significantly influence hemostatic efficacy and healing.
• Various fabrication methods offer distinct advantages and limitations for tailored hemostat design.

Conclusions:

• Advanced fabrication technologies enable the creation of sophisticated 3D hemostats.
• Optimizing 3D topography and biomaterial composition is key to enhancing hemostatic and regenerative functions.
• This review provides insights for developing next-generation smart hemostats for tissue engineering.