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Effects of primary angle-closure glaucoma on interhemispheric functional connectivity.

Yongqiang Shu1, Yuying Huang1, Jingting Chen1

  • 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Neuroscience
|February 27, 2023
PubMed
Summary

Primary angle-closure glaucoma (PACG) patients show altered brain connectivity, particularly in visual and sensorimotor networks. These brain changes may explain visual impairments and help differentiate PACG from healthy individuals.

Keywords:
functional connectivityfunctional magnetic resonance imagingglaucomaresting statevoxel-mirrored homotopic connectivity

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Previous research on primary angle-closure glaucoma (PACG) focused on localized brain regions or global activity.
  • Interhemispheric functional homotopy and its link to brain-wide connectivity abnormalities in PACG remain understudied.
  • The potential of brain functional alterations to distinguish PACG patients from healthy controls (HCs) and correlate with neurocognitive impairment is largely unknown.

Purpose of the Study:

  • To investigate alterations in interhemispheric functional homotopy in PACG patients.
  • To explore the relationship between altered brain connectivity and clinical parameters in PACG.
  • To assess the utility of brain functional connectivity patterns in classifying PACG.

Main Methods:

  • Recruited 40 PACG patients and 40 age/sex-matched HCs.
  • Utilized resting-state functional magnetic resonance imaging (rs-fMRI) and voxel-mirrored homotopic connectivity (VMHC).
  • Employed whole-brain functional connectivity analysis and support vector machine (SVM) for classification.

Main Results:

  • PACG patients exhibited significantly decreased VMHC in the lingual gyrus, insula, cuneus, and pre/post-central gyri compared to HCs.
  • Extensive functional network changes were observed, notably in default mode, salience, visual, and sensorimotor networks.
  • The SVM model achieved an AUC of 0.85 for PACG classification.

Conclusions:

  • Altered functional homotopy in the visual cortex, sensorimotor network, and insula may contribute to visual dysfunction in PACG.
  • PACG patients may experience impaired visual information interaction and integration.
  • Brain functional connectivity analysis shows promise for differentiating PACG and understanding its neurological underpinnings.