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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
247
Diabetes Mellitus and the Kidneys.
Arnon Gal1, Richard K Burchell2
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, IL 61802, USA.
The Veterinary Clinics of North America. Small Animal Practice
|February 28, 2023
Summary
Diabetic kidney disease mechanisms exist in pets, but chronic kidney disease is rarely seen in diabetic dogs and cats. Further research is needed to understand these potential renal complications.
Area of Science:
- Veterinary Medicine
- Nephrology
- Endocrinology
Background:
- Diabetic kidney disease (DKD) in humans shares pathological mechanisms with those potentially occurring in companion animals.
- Long-standing diabetes mellitus in pets may theoretically predispose them to renal complications.
Purpose of the Study:
- To explore the potential for diabetic kidney disease development in companion animals.
- To assess the clinical evidence of chronic kidney disease secondary to diabetes mellitus in dogs and cats.
Main Methods:
- Review of existing literature on diabetic nephropathy in humans and companion animals.
- Analysis of clinical data and case studies regarding renal complications in diabetic pets.
Main Results:
- Pathomechanisms of DKD are conserved across species, including dogs and cats.
- Clinical evidence for chronic kidney disease developing from diabetes mellitus in companion animals is currently limited.
- Renal complications, if they occur, appear to develop over extended periods.
Conclusions:
- While theoretical risks exist, overt chronic kidney disease due to diabetes mellitus is not well-documented in companion animals.
- Further clinical investigation is warranted to fully understand the long-term renal impact of diabetes mellitus in pets.
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