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State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
Multimodality Imaging in Noonan Syndrome: Case Series of Young Children
Wenjing Yang1, Yining Wang1, Arlene Sirajuddin1
1Departments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).
Abstract:
Noonan syndrome (NS) is an autosomal dominant disorder characterized by distinctive facial anomalies, growth failure, and a wide spectrum of cardiac abnormalities. Here, the clinical presentation, multimodality imaging characteristics, and management in a case series of four patients with NS are presented. Multimodality imaging showed frequently biventricular hypertrophy accompanied by biventricular outflow tract obstruction and pulmonary stenosis, similar late gadolinium enhancement pattern, and elevation of native T1 and extracellular volume, which may serve as multimodality imaging features in NS to aid in patient diagnosis and treatment. Keywords: Pediatrics, Echocardiography, MR Imaging, Cardiac Supplemental material is available for this article. © RSNA, 2023.
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