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Updated: Aug 8, 2025
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Lung stereotactic body radiation therapy using simultaneous integrated BED-escalation for peripherally located
Colton J Ladbury1, Sagus Sampath1
1Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, USA.
Purpose:
Report the outcomes of patients with non-small cell lung cancer (NSCLC) and peripheral tumors treated with simultaneous integrated biologically equivalent dose (BED)-escalation (SIBE) lung stereotactic body radiation therapy (SBRT) to achieve dose escalation.
Materials/Methods:
Patients with NSCLC within 5 mm of the chest wall treated with a SIBE approach were eligible. Patients received 60 Gy in 5 fractions, with dose decreased to 50 Gy based on proximity to the chest wall. Dosimetry, oncologic outcomes, and toxicity were evaluated.
Results:
Twenty-four patients met inclusion criteria. Median BED to the PTV was 135.4 Gy. Median chest wall V30 was 18.7 cc. The 3-year LC, OS, and PFS of the non-metastatic cohort was 93%, 35%, and 39%, respectively. The crude rate of chest wall toxicity was 12.5%, with no rib fractures.
Conclusions:
SIBE lung SBRT appears to be well tolerated and achieves favorable local control rates and survival.
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