Electrochemical Difluoromethylation of Electron-Rich Olefins
Shinan Luan1, Thomas Castanheiro1, Thomas Poisson1
1Normandy Univ. INSA Rouen Normandy, UNIROUEN, CNRS COBRA (UMR 6014), 76000 Rouen, France.
Abstract:
The electrochemical difluoromethylation of electron-rich olefins (enamides and styrene derivatives) is disclosed. The addition of the electrogenerated difluoromethyl radical from the corresponding sodium sulfinate (i.e., HCF2SO2Na) to enamides and styrenes in an undivided cell allowed the formation of a large panel of difluoromethylated building blocks in good to excellent yields (42 examples, 23-87% yields). A plausible unified mechanism was suggested according to control experiments and cyclic voltammetry measurements.
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