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Localized transverse flow measurement with dynamic light scattering line-scan OCT.
Le Han1, Bingyao Tan2,3,4, Leopold Schmetterer2,3,4,5,6,7,8
1Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Biomedical Optics Express
|March 6, 2023
Summary
A new decorrelation method precisely measures localized transverse flow velocity using line-scan optical coherence tomography (LS-OCT). This technique separates flow components, enabling detailed velocity mapping for various applications.
Area of Science:
- Biomedical Optics
- Fluid Dynamics
- Medical Imaging
Background:
- Accurate measurement of localized flow velocity is crucial in various scientific and medical fields.
- Existing optical coherence tomography (OCT) methods face challenges in separating complex flow dynamics and noise.
Purpose of the Study:
- To introduce a novel decorrelation-based approach for measuring localized transverse flow velocity.
- To enable the separation of flow velocity components from diffusion and noise in OCT signals.
Main Methods:
- Development of a decorrelation-based algorithm for line-scan (LS) OCT.
- Separation of the flow velocity component along the line-illumination direction.
- Verification using flow imaging in glass capillaries and microfluidic devices.
Main Results:
- Successfully measured localized transverse flow velocity with enhanced accuracy.
- Mapped the spatial distribution of flow velocity within the imaging plane.
- Demonstrated the method's ability to distinguish flow from diffusion and noise.
Conclusions:
- The proposed decorrelation method offers a robust way to measure localized transverse flow velocity using LS-OCT.
- This technique provides valuable insights into fluid dynamics in microscale systems.
- Future extensions can enable 3D flow velocity mapping for ex vivo and in vivo applications.
